Quinolines and derivatives
- (1)
- (1)
- (1)
- (219)
- (6)
- (40)
- (2)
- (12)
- (47)
- (1)
- (37)
- (1)
- (2)
- (1)
- (1)
- (1)
- (4)
- (1)
- (1)
- (7)
- (132)
- (1)
- (9)
- (16)
- (1)
- (35)
- (1)
- (1)
- (1)
- (1)
- (1)
- (189)
- (1)
- (1)
- (15)
- (1)
- (17)
- (17)
- (7)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (2)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (2)
- (7)
- (22)
- (26)
- (30)
- (4)
- (6)
- (1)
- (4)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (2)
- (5)
- (2)
- (6)
- (5)
- (2)
- (1)
- (11)
- (1)
- (2)
- (1)
- (4)
- (1)
- (1)
- (1)
- (1)
- (2)
- (1)
- (1)
- (1)
- (25)
- (16)
- (2)
- (3)
- (1)
- (1)
- (2)
- (2)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (4)
- (4)
- (4)
- (8)
- (2)
- (1)
- (2)
- (1)
- (1)
- (6)
- (2)
- (1)
- (1)
- (2)
- (1)
- (6)
- (1)
- (20)
- (1)
- (5)
- (1)
- (3)
- (5)
- (1)
- (2)
- (2)
- (2)
- (2)
- (8)
- (1)
- (1)
- (2)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (4)
- (3)
- (1)
- (2)
- (1)
- (1)
- (1)
- (4)
- (2)
- (2)
- (1)
- (1)
- (2)
- (3)
- (1)
- (1)
- (1)
- (1)
- (2)
- (1)
- (1)
- (2)
- (5)
- (1)
- (2)
- (5)
- (2)
- (4)
- (2)
- (3)
- (1)
- (3)
- (1)
- (1)
- (1)
- (1)
- (1)
- (3)
- (1)
- (2)
- (1)
- (1)
- (1)
- (1)
- (1)
- (3)
- (1)
- (4)
- (2)
- (4)
- (1)
- (1)
- (3)
- (3)
- (1)
- (7)
- (2)
- (1)
- (4)
- (1)
- (1)
- (1)
- (2)
- (4)
- (1)
- (2)
- (1)
- (1)
- (2)
- (3)
- (2)
- (1)
- (1)
- (1)
- (1)
- (2)
- (1)
- (2)
- (1)
- (1)
- (2)
- (2)
- (2)
- (3)
- (2)
- (1)
- (1)
- (2)
- (2)
- (2)
- (1)
- (4)
- (1)
- (2)
- (3)
- (1)
- (1)
- (1)
- (1)
- (1)
- (13)
- (1)
- (2)
- (2)
- (4)
- (3)
- (4)
- (1)
- (1)
- (2)
- (2)
- (1)
- (2)
- (1)
- (2)
- (19)
- (2)
- (1)
- (2)
- (4)
- (1)
- (1)
- (2)
- (2)
- (2)
- (2)
- (2)
- (1)
- (2)
- (1)
- (1)
- (2)
- (1)
- (4)
- (5)
- (1)
- (2)
- (1)
- (1)
- (2)
- (4)
- (3)
- (2)
- (1)
- (9)
- (2)
- (3)
- (3)
- (2)
- (5)
- (3)
- (13)
- (2)
- (1)
- (1)
- (2)
- (2)
- (2)
- (2)
- (1)
- (1)
- (3)
- (2)
- (2)
- (1)
- (2)
- (1)
- (2)
- (2)
- (2)
- (1)
- (1)
- (2)
- (2)
- (2)
- (2)
- (2)
- (2)
- (4)
- (5)
- (4)
- (3)
- (3)
- (7)
- (1)
- (2)
- (3)
- (7)
- (5)
- (2)
- (1)
- (10)
- (1)
- (1)
- (1)
- (2)
- (2)
- (4)
- (1)
- (2)
- (2)
- (4)
- (2)
- (2)
- (6)
- (2)
- (7)
- (4)
- (3)
- (2)
- (2)
- (5)
- (2)
- (1)
- (14)
- (1)
- (1)
- (23)
- (42)
- (24)
- (18)
- (83)
- (3)
- (17)
- (3)
- (5)
- (8)
- (1)
- (6)
- (1)
- (5)
- (1)
- (6)
- (5)
- (2)
- (5)
- (2)
- (6)
- (2)
- (2)
- (4)
- (1)
- (26)
- (19)
- (70)
- (110)
- (3)
- (1)
- (2)
- (59)
- (5)
- (1)
- (1)
- (2)
- (299)
- (2)
- (2)
- (4)
- (2)
- (5)
- (1)
- (1)
- (1)
- (1)
- (3)
- (9)
- (3)
- (2)
- (62)
- (2)
- (29)
- (3)
- (1)
- (1)
- (3)
- (3)
- (2)
- (1)
- (2)
- (1)
- (5)
- (4)
- (2)
- (1)
- (3)
- (1)
- (2)
- (2)
- (5)
- (3)
- (2)
- (3)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (1)
- (12)
- (4)
- (1)
- (5)
- (3)
- (5)
- (2)
- (2)
- (3)
- (2)
- (1)
- (1)
- (3)
- (1)
- (3)
- (1)
- (2)
- (1)
- (1)
- (1)
- (1)
- (1)
Filtered Search Results
Alkali Scientific ALKALI SCIENTIFIC INC
5000659620 ETHIDIUM BROMIDE DNA STAIN
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
![Medchemexpress LLC 3-(2,4-dimethoxyphenyl)-4-(3-thienyl)-1H-pyrrolo[2,3-b]pyridine | 1613710-01-2 | 99.7% | 200 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000233699.png-250.jpg)
Medchemexpress LLC 3-(2,4-dimethoxyphenyl)-4-(3-thienyl)-1H-pyrrolo[2,3-b]pyridine | 1613710-01-2 | 99.7% | 200 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
ARN-3236 (CAS 1613710-01-2) is an orally active, selective inhibitor of salt-inducible kinase 2 (SIK2) used for research applications. It potently inhibits SIK2 at sub-nanomolar concentrations, demonstrates anti-cancer activity in cell-based assays, and can sensitize cancer cells to paclitaxel-class agents.
- Oral active selective SIK2 inhibitor.
- IC50 for SIK2 <1 nM; SIK1 21.63 nM; SIK3 6.63 nM.
- Purity greater than 98.0% (HPLC).
- Molecular weight 336.41 g/mol; formula C19H16N2O2S.
- Available as solid and DMSO solution; multiple sizes including 200 mg.
- Intended for research use only; not for human use.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
eMolecules 7-HYDROXYQUINOLINE-6-CAR 0.25G
5000225524 7-HYDROXYQUINOLINE-6-CAR 0.25G
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
eMolecules N2-FMOC-N6- ALLYLOXYCARBO 1G
5000162166 N2-FMOC-N6- ALLYLOXYCARBO 1G
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Apexbio Technology LLC Apixaban 503612-47-3 200mg
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Apixaban (CAS 503612-47-3) is a highly selective reversible inhibitor of coagulation Factor Xa with Ki values of 0 08 nM and 0 17 nM for human and rabbit enzymes respectively By targeting Factor Xa a central serine protease in the coagulation cascade apixaban effectively impedes thrombin generation and subsequent clot formation In vitro apixaban prolongs coagulation parameters in human plasma at submicromolar concentrations and demonstrates potent antithrombotic activity across multiple animal models With favorable pharmacokinetics including high oral bioavailability and low clearance in preclinical studies apixaban serves as a valuable tool for investigating coagulation mechanisms and evaluating anticoagulant strategies
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Medchemexpress LLC Almonertinib mesylate | 2134096-06-1 | 99.7% | 621.75 | 25 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Almonertinib mesylate (HS-10296 mesylate) is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. It shows great inhibitory activity against T790M, T790M/L858R, and T790M/Del19 (IC50: 0.37, 0.29, and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). It is used for the research of non-small cell lung cancer, and can also inhibit other EGFR sensitive mutations, including G719X, del19, L858R, and L861Q.
- Orally available
- Irreversible
- Third-generation EGFR tyrosine kinase inhibitor
- High selectivity for EGFR-sensitizing and T790M resistance mutations
- Great inhibitory activity against T790M, T790M/L858R and T790M/Del19
- Used for research of non-small cell lung cancer
- Inhibits EGFR sensitive mutations (G719X, del19, L858R, L861Q)
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Medchemexpress LLC ROSIGLITAZONE HYDRO | 200MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
ROSIGLITAZONE HYDRO | 200MG
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
eMolecules METHYL 2-QUINOLIN-6-YLAC 25G
5000159857 METHYL 2-QUINOLIN-6-YLAC 25G
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Apexbio Technology LLC Leukadherin 1 344897-95-6 200mg
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Leukadherin 1 (CAS 344897-95-6) is a small molecule agonist of the integrin CD11b/CD18 a cell surface adhesion receptor predominantly expressed on innate immune cells By activating CD11b/CD18 Leukadherin 1 enhances cell adhesion to fibrinogen with an EC50 of 4 M and increases CD11b/CD18-mediated adhesion to ICAM-1 In cellular models such as K562 cells it promotes membrane tether formation facilitating integrin-ligand interactions In vivo Leukadherin 1 reduces neutrophil accumulation in mouse models of acute peritonitis and decreases leukocyte infiltration and tissue injury in models of kidney transplantation and hyperoxia-induced lung injury This compound serves as a research tool for investigating integrin-mediated leukocyte functions and inflammatory processes
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Medchemexpress LLC 7-Bromoquinoline | 4965-36-0 | 208.06 | 10 G
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
7-Bromoquinoline is a biochemical reagent utilized in life science research. It serves as both a biological material and an organic compound for various scientific applications.
- Functions as a biochemical reagent
- Suitable for use as a biological material in research
- Functions as an organic compound in research
- Designed for life science related research applications
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Medchemexpress LLC MEDCHEMEXPRESS LLC
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
5000377781 ENTOSPLETINIB 200MG
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Medchemexpress LLC STF-31 | 724741-75-7 | 97.0% | 423.53 | 10 MM 1 ML
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
STF-31 is a selective inhibitor of glucose transporter 1 (GLUT1) with an IC50 of 1 μM. It also functions as a NAMPT inhibitor and inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells.
- Targets GLUT
- Targets Autophagy
- Used in cancer research
- Cited in over 15 publications
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Medchemexpress LLC MEDCHEMEXPRESS LLC
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
5000665661 PT2399 200MG
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Apexbio Technology LLC Olmutinib (HM61713, BI 1482694) 1353550-13-6 200mg
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Olmutinib (HM61713 BI 1482694 CAS 1353550-13-6) is an irreversible mutant-selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase It covalently binds to a cysteine residue near the EGFR kinase domain particularly targeting mutant forms such as L858R/T790M and exon 19 deletion In cellular assays Olmutinib demonstrated potent inhibition of EGFR signaling in NSCLC cell lines H1975 (L858R/T790M GI50 9 2 nM) and HCC827 (exon 19 deletion GI50 10 nM) while showing low activity against wild-type EGFR cell lines It exhibits prolonged inhibitory effects ( 24 h) on EGFR activity and demonstrates in vivo antitumor efficacy in xenograft models without significant adverse effects Olmutinib serves as a tool for studying third-generation EGFR TKI resistance mechanisms in NSCLC
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More
Medchemexpress LLC Darunavir Ethanolate | 635728-49-3 | 99.9% | 593.73 | 200 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Darunavir ethanolate (TMC114 Ethanolate) is a potent HIV protease inhibitor used to treat and prevent HIV/AIDS. It has a Ki of 1 nM for wild type HIV-1 protease.
- Broad-spectrum potent inhibitor active against HIV-1 clinical isolates with minimal cytotoxicity.
- Forms hydrogen bonds with the conserved main-chain atoms of Asp29 and Asp30 of the protease, critical for potency against HIV isolates resistant to multiple protease inhibitors.
- Shows greater potency than other inhibitors in MT-2 cells.
- Primarily metabolized by hepatic cytochrome P450 (CYP) enzymes, mainly CYP3A.
- Is effective against wild-type and PI-resistant HIV.
- Has an oral bioavailability of 37%, which increases to 82% when combined with ritonavir.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More